1. Water is essential for human survival; we cannot live without it for more than a few days. - основа основ, необходимый
2. The discovery of penicillin was a significant breakthrough in the field of medicine, leading to the treatment of many bacterial infections. - важный по значению, применению
3. Sarah's organizational skills made her an indispensable member of the project team; they couldn't imagine completing the work without her. - незаменимый