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Since this is windows, you can download an installer that will assist the install of the agent on the host.
But since this host is on a different network that the Zabbix-Server, and a Zabbix Proxy is not present, we will need to create a firewall rule to port forward external Zabbix server initiated commands to the internal hosts IP and port.
I install the Zabbix agent on windows listening on the default port of 10050.
I get it's external IP address, and enter that into the Zabbix Server hosts setup for this windows host, and then setup the port forwarding rule on my router.
Zabbix server isn't on the same network as my new Windows host, so the windows hosts internal IP will not work without setting up a specific firewall forwarding rule.
After all configurations have been entered, you can open the services panel on windows and restart the Zabbix agent service so that the agent and server begin communicating.